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. 2018 Apr 18;9(1):707–720. doi: 10.1080/21505594.2018.1435249

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Virulence of M. circinelloides CBS277.49 and NRRL3631 strains in neutropenic murine host. Survival of mice infected (A) intravenously (i.v.) with 1 × 10⁶ and 1 × 10⁵ CFU of fungal strains and (B) intranasally (i.n.) with 5 × 10⁷ CFU of fungal strains show significant lower virulence of NRRL 3631 (*) (p < 0.05). (C) Fungal biomass quantification of liver, brain, kidney lung and spleen 3 days after i.v. infection with 1 × 10⁶ CFU/animal of CBS277.49 and NRRL3631 using real-time PCR. Data represent µg of fungal biomass respect 1 g of mice tissue biomass. Significant differences are indicated (*). Bars indicate the standard deviation from independent experiments.