Figure 1.

Effect of ceftazidime and imipenem on K. pneumoniae RJA166 infection in murine model. (a) The survival curve of the BALB/c mice infected with 1.8 × 10³ CFU of Klebsiella pneumoniae RJA166 with different treatments. In the 14 days after bacteria challenge, mice treated by imipenem (20 mg/kg), ceftazidime (40 mg/kg) and saline (0.9%) showed mortalities of 30%, 70% and 100%, respectively. (b) The bacterial load of murine tissues in the mice treated with different antibiotic. The results were calculated by dividing the quantity of bacterial gyrase gene by the quantity of murine β-actin gene. The bacterial loads in the kidneys, spleens and livers from the mice treated with ceftazidime were significantly higher than those in the mice treated with imipenem, with the p value 0.0383, <0.0001 and <0.0001, respectively, as generated by Student's t test.