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. 2017 Jun 1;9(1):83–98. doi: 10.1080/21505594.2017.1326443

Figure 7.

Figure 7.

Silence of autophagy related genes, LC3-II and beclin1, inhibits rotavirus replication. (A) Western blot detected LC3-II protein in lentiviral RNAi against LC3-II transduced Caco2 cells. (B) LC3-II knockdown increased rotavirus genomic RNA determined by qRT-PCR (n = 4–10, mean ± SEM, *P < 0.05, **P < 0.01, Mann-Whitney test). (C) LC3-II knockdown increased rotavirus VP4 protein synthesis detected by western blot assay. (D) Western blot detected beclin1 protein in lentiviral RNAi against beclin1 transduced Caco2 cells. (E) Beclin1 knockdown increased rotavirus genomic RNA determined by qRT-PCR (n = 11–17, mean ± SEM, ***P < 0.001, Mann-Whitney test). (F) Beclin1 knockdown increased rotavirus VP4 protein synthesis detected by western blot assay.