Figure 2.

Relationship between change in 25(OH) and carotid bulb IMT. Scatter plots depict the bivariate relationship between changes in serum 25(OH)D concentrations and changes in carotid bulb IMT for (A). all HIV-subjects combined (R = 0.43; P = 0.001) and (B) shown by dosing arm separately (standard-dose arm: R = -0.05, P = 0.86; supplementation-dose arm: R = 0.47, P = 0.004). Increases in carotid bulb IMT were significantly correlated with increases in serum 25(OH)D concentrations, with this association driven by subjects in the supplementation arm. R, Spearman correlation coefficient. IMT, intima-media thickness; 25(OH)D, 25-hydroxyvitamin D