Fig 1. IL-1β synergizes with IL-17 to produce IL-6, independently from Cd exposure.

Time course of IL-6 production in supernatants of synoviocytes exposed to cytokine combinations. Red lines indicate the chosen condition to perform the next experiments. Data are represented as mean ± SEM of at least three independent experiments; * shows differences between non-inflammatory and inflammatory conditions, # shows differences due to Cd addition; */# p<0.05, **/##p<0.01.