. Author manuscript; available in PMC: 2019 May 1.

Published in final edited form as: J Allergy Clin Immunol. 2018 Jan 12;141(5):1582–1586.e1. doi: 10.1016/j.jaci.2017.11.046

TABLE I.

Complement components produced by airway epithelial cells

Components	Evidence	Primary cell data	Tissue data
Classical pathway

C1q	Not expressed^E1

C1r	mRNA^E2–E5	Zhou et al^E2
	Protein^E6

C1s	mRNA^E3,E7
	Protein^E6

C4	mRNA^E8–E10	Scheetz et al^E9
	Protein^E6	Walters et al^E10
	Supernatant^E11,E12	Peters-Hall et al^E11
		Brass et al^E12

C2^*	mRNA^E8

Lectin pathway

MBL	mRNA^E5,E13		Vandermeer et al^E13

H-ficolin	mRNA^E14		Akaiwa et al^E14
	Protein^E14,E15

Alternative pathway

C3	mRNA^{E7,E8,E16–E18}	Ali et al^E20	Schlosser et al^E17
	Protein^E6,E18,E19	Pillai et al^E21	Lane et al^E18
	Supernatant^{E1,E16,E20,E21}

Factor B	mRNA^{E8,E13,E16,E17,E22}	Peters-Hall et al^E11	Vandermeer et al^E13
	Protein^E6	Brass et al^E12	Schlosser et al^E17
	Supernatant^{E11,E12,E16,E21}	Pillai et al^E21
		Cooper et al^E22

Factor D	No data and not expected to occur (primary source: adipocytes)

Properdin^*	mRNA^E13,E18,E23		Vandermeer et al^E13
			Lane et al^E18

Terminal complement complex

C5	mRNA^E7,E8,E17		Supernatant^E24
	Protein^E6
	Schlosser et al^E17

C6, C7, C8, C9^*	mRNA^E6,E17,E25		Schlosser et al^E17
	Protein^E6		Ying et al^E25

Regulators, fluid phase

C1INH	No data

C4BP^*	Supernatant^E26,E27

Factor H	mRNA^E13,E28	Pillai et al^E21	Vandermeer et al^E13
	Protein^E6
	Supernatant^E21,E28

Factor I	mRNA^E13
	Protein^E6
	Supernatant^E21,E26

Clusterin	mRNA^E5,E29	Peters-Hall et al^E11
	Supernatant^E11	Hackett et al^E29

Regulators, membrane bound

CD46 (MCP)	mRNA^E26,E30		Suzuki et al^E32
CD46 (MCP)	Protein^E1,E31–E33		Varsano et al^E33

CD55 (DAF)	mRNA^E34–E37	Agrawal et al^E34	Suzuki et al^E32
	Protein^{E1,E32,E33,E35,E37}	Pandya et al^E35	Varsano et al^E33
	Supernatant (shedding)^E36		Vainer et al^E37

CD59	mRNA^E4,E38	Brass et al^E12	Varsano et al^E33
	Protein^E1,E33,E39	Ali et al^E20
	Supernatant (shedding/exosomes)^E12,E20,E40	Castillon et al^E39
		Kesimer et al^E40

Receptors

C3aR1	mRNA^E41	Drouin et al^E41	Drouin et al^E41
	Protein^E41–E43		Fregonese et al^E42

C5aR1	mRNA^E29,E41	Hackett et al^E29	Gu et al^E43
	Protein^E41–E43	Drouin et al^E41

C5aR2	No data

CR1 (CD35)	Not expressed^E33

Components that are not expressed or have no data supporting their production by airway epithelial cells are indicated by italics in the Evidence column. Evidence for protein content was based on immunoblotting, flow cytometry, or mass spectrometry of the cells/cell lysate. Supernatant denotes that the cells secreted the protein, unless otherwise specified (in which case it was either shed or secreted as exosomes).

C1INH, C1-inhibitor; C4BP, C4b-binding protein; DAF, decay-accelerating factor; MBL, mannose-binding lectin; MCP, membrane cofactor protein.

Studies from a single research group or conflicting evidence existing in the literature.