Table 2.
Ongoing Vitamin D Clinical Trials
| Trial name | Country | Population | Intervention | Main outcomes | Results expected |
|---|---|---|---|---|---|
| SIMPLIFIED (Survival Improvement with Cholecalciferol in Patients on Dialysis) | United Kingdom | 4,200 adults, aged > 18 years | Cholecalciferol 60,000 IU fortnightly | Mortality, health-relatedquality of life, hospital admission, cardiovascular events, cancer incidence | 2023 |
| VIDAL (Vitamin D and Longevity trial) | United Kingdom | 20,000 adults, 65–85 years old | 100,000 IU D3 monthly, placebo or open control | Mortality, morbidity (infections, doctor’s visits, cancer) and vitamin D levels | 2020 |
| FIND (Finnish Vitamin D Trial) | Finland | 18,000 adults, men > 60 years and women > 65 years | 3200 D3 daily, 1600 D3 daily or placebo | Cardiovascular disease, cancer and diabetes mellitus | 2019 |
| DOHealth (Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial) | Europe | 2150 adults aged > 70 years | 2000 IU D2 or placebo | Bone fractures, infection, blood pressure, cognition and lower extremity function | 2017–2018 |
| TARGET-D (Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients) | United States | 890 adults, aged > 18 years | Target 25[OH]D levels > 40ng/mL with cholecalciferol or standard of care (no intervention) | Mortaliy, myocardial infarction, heart failure hospitalization and cerebral vascular accident | 2021 |
| Magnesium and Vitamin D Supplementation and Cardiometabolic Outcomes | United States | 123 adults, aged 30 to 70 years | 1000U vitamin D and 360 magnesium vs 1000U vitamin D vs placebo | PTH levels, inflammatory cytokines, lipid profile, blood pressure, serum osteocalcin | 2020 |
| Effect of Vitamin D on Ventricular Remodeling in Patients with Acute Myocardial Infarction (VITDAMI) | Spain | 144 adults, aged 40 to 85 years | 15,690 IU Calcifedioll vs placebo | Change in cardiac remodeling by MRI, echo parameters | 2017–2018 |
| Effect of Vitamin D Supplementation in Patients with Heart Failure and Vitamin D Deficiency | Mexico | 60 adults, aged 45 to 85 years | 5 000IU vitamin D D vs placebo | Myocardial structure and function by MRI, myocardial infarction | 2018 |