. Author manuscript; available in PMC: 2018 Aug 1.

Published in final edited form as: Nat Rev Neurosci. 2017 Jun 22;18(8):459–469. doi: 10.1038/nrn.2017.71

Table 1. Cell type-specific manipulations in the thirst circuit.

Pathway	Genetic marker	Manipulation	Neural activity	Water intake	Food intake	Sodium intake
SFO^GLUT somas	Camk2^13,16, Etv1¹³, Nos1^14,16	ChR2	↑	↑^13,14,16	– ^13,14,16	↑¹³
SFO^GLUT somas	Camk2 ¹⁵, Nos1 ¹⁴	G_q-DREADDs	↑	↑^14,15	– ¹⁴	↑¹⁵
SFO^GLUT somas	Nos1¹⁶	Arch	↓	↓	↑	N.R.
SFO^GLUT→MnPO	Camk2 ¹⁶	ChR2	↑	↑	N.R.	N.R.
SFO^GLUT→PVH	Camk2 ¹⁶	ChR2	↑	–	N.R.	N.R.
SFO^GLUT→OVLT	Slc17a6 ²¹	ChR2	↑	↑	N.R.	–
SFO^GABA+GLUT→OVLT	–²¹	Arch	↓	↓	N.R.	–
SFO^GLUT→BNSTvl	Slc17a6 ²¹	ChR2	↑	–	N.R.	↑
SFO^GLUT→BNSTvl	–²¹	Arch	↓	–	N.R.	↓
SFO^GABA somas	Slc32a1^13,21	ChR2	↑	↓^13,21	– ¹³	– ¹³, ↓²¹
MnPO/OVLT^GLUT somas	Slc17a6¹⁷	ChR2	↑	↑	N.R.	N.R.
MnPO/OVLT^GABA somas	Slc17a6¹⁷	ChR2	↑	↓	–	N.R.
SCN^AVP→OVLT	Avp¹⁸	ChR2	↑	↑	N.R.	N.R.
SCN^AVP→OVLT	Avp¹⁸	Arch	↓	↓	N.R.	N.R.
NTS^HSD2 somas	Hsd11b2²⁰	G_q-DREADDs	↑	–	↓	↑
NTS^HSD2 somas	Hsd11b2²⁰	G_i-DREADDs	↓	–	N.R.	↓
NTS^HSD2 somas	Hsd11b2²⁰	TetTox	↓	Fatal (>20% body weight lost byday 10)