Table 1. Summary of the infertility treatment after ovarian tissue transplantation.
Months after transplantation | MCD #3 E2, pg/mL; FSH, mIU/L; AMH, ng/mL | COS regimen, duration | Diameter of the developed follicles, mm | Peak E2, pg/mL | Results |
---|---|---|---|---|---|
3 | E2 57; FSH 43.69; AMH 0.08 | Natural cycle | RO 15 | - | Cycle cancellation due to no further growth |
5 | CC 50 mg, 5 days | No growth | - | Cycle cancellation | |
7 | CC 100 mg, 5 days | RO 15 | 41 | Cycle cancellation due to no further growth | |
→ LT 2.5 mg, 5 days | |||||
→ hMG 225 IU, 3 days | |||||
→ rFSH 225 IU, 10 days | |||||
10 | CC 50 mg, 5 days | RO 18.5 | 276 | Oocyte retrieved (GV × 1) | |
Embryo transferred (6 cell grade III/IV × 1, on day 3) | |||||
→ No pregnancy | |||||
11 | LT 2.5 mg, 5 days | RO 16.5, 14, 13 | 168 | Follicle ruptured before TVOA and changed to IUI | |
→ CC 50 mg, 5 days | → No pregnancy | ||||
→ hMG 225 IU, 9 days | |||||
13 | CC 50 mg, 5 days | RO 19 | 135 | Follicle ruptured before TVOA and changed to IUI | |
→ LT 2.5 mg, 5 days | → No pregnancy | ||||
→ hMG 75 IU, 1 days | |||||
14 | CC 50 mg, 5 days | RO 17 | 88 | No oocyte retrieved after TVOA | |
→ hMG 225 IU, 3 days | |||||
15 | CC 50 mg, 5 days | No growth | - | Cycle cancellation | |
→ CC 100 mg, 5 days | |||||
→ hMG 225 IU, 9 days | |||||
16 | CC 50 mg, 5 days | No growth | - | Cycle cancellation | |
18 | E2 89; FSH 42.06; AMH 0.03 | CC 100 mg, 5 days | RO 17.5 | 314 | No oocyte retrieved after TVOA |
→ CC 150 mg, 5 days | |||||
→ hMG 150 IU, 2 days | |||||
19 | CC 100 mg, 5 days | No growth | - | Cycle cancellation | |
→ LT 2.5 mg, 5 days |
MCD = menstrual cycle day, FSH = follicle-stimulating hormone, AMH = anti-microbial handwash, CC = clomiphene citrate, COS = controlled ovarian stimulation, GV = germinal vesicle, hMG = human menopausal gonadotropin (Menopur®; Ferring SA, Madrid, Spain), IUI = intrauterine insemination, LT = Letrozole, rFSH = recombinant follicle-stimulating hormone (Gonal-F®; Merck Serono, Darmstadt, Germany), RO = right ovary, TVOA = transvaginal oocyte aspiration.