Table 1. KO mouse lines with impaired sperm-ZP binding in vitro and impaired sperm migration from uterus into the oviduct.

Gene	Expression pattern	Localization	Phenotype of KO mice			Human ortholog	References
			In vitro sperm-ZP binding ability	Sperm migration ability to oviduct	Localization of ADAM3 on spermatozoa
Ace-t	Sperm	Sperm surface	Impaired	Impaired	Aberrantly localized	+	Krege JH, et al. 1995; Yamaguchi R, et al. 2006
Adam1a	Testis	Endoplasmic reticulum	Impaired	Impaired	Disappeared	–	Nishimura H, et al. 2004
Adam2	Sperm	Sperm surface	Impaired	Impaired	Disappeared	+	Cho C, et al. 1998
Adam3	Sperm	Sperm surface	Impaired	Impaired	Disappeared	–	Shamsadin R, et al. 1999; Yamaguchi R, et al. 2009
Calr3	Testis	Endoplasmic reticulum	Impaired	Impaired	Disappeared	+	Ikawa M, et al. 2011
Clgn	Testis	Endoplasmic reticulum	Impaired	Impaired	Disappeared	+	Ikawa M, et al. 1997
Ly6k	Testis	Testicular germ cell	Impaired	Impaired	Localized	+	Fujihara Y, et al. 2014
Pdilt	Testis	Endoplasmic reticulum	Impaired	Impaired	Disappeared	+	Tokuhiro K, et al. 2012
Pgap1	Ubiquitous	Endoplasmic reticulum	Impaired	Impaired	Localized	+	Ueda Y, et al. 2007
Pmis2	Sperm	Sperm surface	Impaired	Impaired	Disappeared	–	Yamaguchi R, et al. 2012
Prss37	Testis	Testicular germ cell	Impaired	Impaired	Disappeared	+	Shen C, et al. 2013
Rnase10	Epididymis	Epididymis	Impaired	Impaired	Disappeared	+	Krutskikh A, et al. 2012
Tex101	Testis	Testicular germ cell	Impaired	Impaired	Disappeared	+	Fujihara Y, et al. 2013
Tpst2	Ubiquitous	Golgi apparatus	Impaired	Impaired	Disappeared	+	Marcello M, et al. 2011