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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Toxicol Lett. 2018 Mar 31;291:1–10. doi: 10.1016/j.toxlet.2018.03.028

Figure 3. Concentration dependence of reactivation of huAChE by ISQ.

Figure 3

HuAChE was incubated with either A. paraoxon for 15 minutes or B. DFP for 10 minutes before addition of the indicated concentrations of ADQ (red-brown) or a less toxic analog, ISQ (teal). Reactivation for paraoxon was allowed for 3 hours, and overnight for DFP. Reactions were diluted 1:100 to reduce background effects from the reactivation compound prior to measurement of enzyme activity. Activities are given relative to activity in the absence of inhibitor or reactivation compound.