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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Toxicol Lett. 2018 Mar 31;291:1–10. doi: 10.1016/j.toxlet.2018.03.028

Figure 6. Initial SAR to determine role of phenyl moiety of Domain C.

Figure 6

Analogs of the initial hit SP138 were synthesized and tested for the concentration dependence of reactivation of huAChE inhibited by DFP. Enzyme was treated with DFP for 10 min. prior to removal of excess DFP by PD10 column. After compounds were added at the indicated concentrations, reactivation was allowed to proceed overnight. Prior to measuring activity, the reactions were diluted 1:100. Each graph shows the controls of SP138 and 2-PAM.