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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Toxicol Lett. 2018 Mar 31;291:1–10. doi: 10.1016/j.toxlet.2018.03.028

Figure 7. Pyridine analogs SP94, SP96, SP98.

Figure 7

Analogs combining features of Group 1 and Group 2 were synthesized and tested for reactivation activity on paraoxon- inhibited muAChE. Paraoxon was incubated with muAChE for 15 minutes prior to removal of excess OPC using a PD10 column. Inhibited enzyme was incubated with the indicated concentrations of compounds for 3 hours. Reactions were diluted 1:100 before measuring enzyme activity.