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A schematic representation of the IQGAP1-scaffolded class I PI3K-Akt signaling platform. IQGAP1 binds to PI4KIIIα, PIPKIα, and class I PI3K that generate PI4P, PI4,5P2, and PI3,4,5P3, respectively. The generated PI3,4,5P3 is directly transferred to PDK1 and Akt, which are also associated with IQGAP1. In the IQGAP1-mediated multi-kinase complex, PI3,4,5P3 generation is tightly linked to its usage.
