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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Exp Neurol. 2018 Mar 14;305:33–43. doi: 10.1016/j.expneurol.2018.03.011

Table 1.

Pathway enrichment analysis of Sciatic Nerve Cluster 2. Significantly enriched canonical pathways among the shared genes in modules 7.6 and 7.7 from the SOM analysis using IPA*

Ingenuity Canonical Pathways p-value Genes
TREM1 Signaling .0380 CXCL3, Naip1, TYROBP, TLR1, TLR7, LAT2, Tlr13, ITGAX
Granulocyte Adhesion and Diapedesis .0380 ITGB2, CXCL3, CLDN15, IL1RN, Ccl8, CCL3L3, MMP8, FPR2, CL17, CCL22, MMP12, IL18RAP
Primary Immunodeficiency Signaling .0380 IL7R, BLNK, PTPRC, ADA, IGHM, Ighg2b
Phagosome Formation .0380 CLEC7A, MSR1, TLR1, TLR7, PIK3R5, FCER1G, Tlr13, Ighg2b, FCGR3A/FCGR3B
Cell Cycle: G2/M DNA Damage Checkpoint Regulation .0380 TOP2A, CCNB2, BORA, PLK1, CDK1, CCNB1
B Cell Development .0380 IL7R, PTPRC, SPN, IGHM, Ighg2b
Agranulocyte Adhesion and Diapedesis .0430 ITGB2, CXCL3, MYH2, CLDN15, IL1RN, Ccl8, CCL3L3, MMP8, MYL4, CCL17, CCL22, MMP12
LPS/IL-1 Mediated Inhibition of RXR Function .0470 FMO2, APOC4, GSTA5, APOC2, GSTO1, IL18RAP, SLC27A5, ALDH1A1, IL1RN, CD14, ABCC3, FABP9, PPARGC1A
Leukocyte Extravasation Signaling .0490 ITGB2, RAC2, NCF1, SPN, ARHGAP9, CLDN15, TIMP1, MMP8, PIK3R5, CYBB, NCF4, MMP12
*

IPA: ingenuity pathway analysis; p-value: Benjamini-Hochberg (BH) corrected p-value.