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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Exp Neurol. 2018 Mar 14;305:33–43. doi: 10.1016/j.expneurol.2018.03.011

Table 3.

Pathway enrichment analysis of Dorsal Root Ganglia Cluster 2. Significantly enriched canonical pathways among the shared genes in modules 1.6 and 1.7 from the SOM analysis using IPA*

Ingenuity Canonical Pathways p-value Molecules
Granulocyte Adhesion and Diapedesis < .0001 CLDN11, SELL, CLDN15, MMP3, IL1RL1, Cldn13, IL1R2, CXCL13, CCL3L3, CXCR2, MMP8, Ccl6, HRH2, C5AR1, SDC1, Ppbp, FPR2, FPR1, SELPLG, Ccl9, IL18RAP, ITGB2, CLDN1, CLDN3, MMP9
Leukocyte Extravasation Signaling < .0001 RAC2, CLDN11, SPN, MMP3, CLDN15, ARHGAP4, Cldn13, NCF4, SELPLG, BTK, ITGB2, TIMP4, NCF1, ARHGAP9, CLDN1, MMP8, CYBA, CYBB, VAV1, ACTG2, MMP9, CLDN3
Agranulocyte Adhesion and Diapedesis < .0001 AOC3, CLDN11, SELL, C5AR1, CLDN15, MMP3, Ppbp, Cldn13, Ccl9, SELPLG, ITGB2, CXCL13, CLDN1, CXCR2, CCL3L3, MMP8, ACTG2, Ccl6, MMP9, CLDN3
Atherosclerosis Signaling .0001 ALOX15, MMP3, CD36, APOC4, CMA1, APOC2, CCR2, PDGFC, TPSAB1/TPSB2, SELPLG, ITGB2, LYZ, S100A8, MMP9, RBP4
LXR/RXR Activation .0003 TTR, IL1RL1, CD36, APOC4, APOC2, IL18RAP, IL1R2, LYZ, LY96, CD14, S100A8, LBP, MMP9, RBP4
Coagulation System .0019 PLG, F10, F5, VWF, F13A1, TFPI, PLAT
Phagosome formation .0081 MRC1, CLEC7A, FCGR2A, TLR7, FCER1A, FCER1G, Tlr13, IGHG1, Ighg2b, FCGR3A/FCGR3B, INPP5D
FcÎ3 Receptor-mediated Phagocytosis in Macrophages and Monocytes .0083 PLD4, RAC2, NCF1, FCGR2A, HCK, VAV1, ACTG2, FCGR3A/FCGR3B, INPP5D, FGR
Complement System .0145 ITGB2, SERPING1, C5AR1, C1QC, CFH, C3AR1
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis .0145 C5AR1, MMP3, IL1RL1, LTB, FZD9, IRAK3, IGHG1, PDGFC, IL18RAP, IL18R1, IL16, IL1R2, F2RL1, TLR7, Tlr13, Ighg2b, FZD2, FCGR3A/FCGR3B, IRAK2
Extrinsic Prothrombin Activation Pathway .0229 F10, F5, F13A1, TFPI
LPS/IL-1 Mediated Inhibition of RXR Function .0269 CYP3A7, FMO2, SLC27A2, IL1RL1, APOC4, GSTA5, APOC2, ALAS1, IL18RAP, IL1R2, LY96, FABP4, CD14, ALDH3B1, LBP
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages .0309 LYZ, NCF1, PTPN6, MPO, MAP3K6, CYBA, APOC4, CYBB, S100A8, APOC2, NCF4, SPI1, RBP4
Hepatic Fibrosis/Hepatic Stellate Cell Activation .0331 CTGF, LEP, IL1RL1, PDGFC, IL18RAP, IL1R2, LY96, COL13A1, PDGFRA, CD14, LBP, MMP9, PDGFRB
Primary Immunodeficiency Signaling .0398 PTPRC, BTK, Igha, IGHG1, Ighg2b, AICDA
Inhibition of Angiogenesis by TSP1 .0437 SDC1, CD36, GUCY1A2, MMP9, GUCY1B3
IL-10 Signaling .0457 IL1R2, CCR1, FCGR2A, IL1RL1, CD14, LBP, IL18RAP
B Cell Receptor Signaling .0490 PTPRC, BTK, RAC2, EBF1, PTPN6, APBB1IP, MAP3K6, FCGR2A, VAV1, IGHG1, Ighg2b, INPP5D
Communication Between Innate and Adaptive Immune Cells .0490 CCL3L3, Igha, TLR7, FCER1G, Tlr13, IGHG1, Ighg2b, Ccl9
Natural Killer Cell Signaling .0490 RAC2, PTPN6, KLRD1, FCGR2A, TYROBP, FCER1G, VAV1, FCGR3A/FCGR3B, INPP5D
*

IPA: ingenuity pathway analysis; p-value: Benjamini-Hochberg (BH) corrected p-value.