Table 4.
Pathway enrichment analysis of Sciatic Nerve DEGs. Significantly enriched canonical pathways among the shared DEGs at all time points using IPA*
| Ingenuity Canonical Pathways | p-value | Genes |
|---|---|---|
| Atherosclerosis Signaling | 5.13E-06 | Pon1, Pla2g2d, Il18, Apoc2, S100a8, Il1rn, Mmp9, Col2a1, Apoc4 |
| Leptin Signaling in Obesity | 1.05E-05 | Pik3r5, Adcy2, Pdia3, Lep, Lepr, Adcy8, Npy |
| Dendritic Cell Maturation | 1.45E-05 | Il18, Il1rn, Hla-Drb5, Hla-Dmb, Pik3r5, Pdia3, Col2a1, Lep, Lepr, Trem2 |
| LXR/RXR Activation | 2.45E-04 | Pon1, Il18, Apoc2, S100a8, Il1rn, Mmp9, Apoc4 |
| Hepatic Cholestasis | 2.63E-04 | Il18, Il1rn, Slco3a1, Adcy2, Prkch, Abcc3, Adcy8, Esr1 |
| Cellular Effects of Sildenafil (Viagra) | 3.63E-04 | Myl4, Prkg2, Adcy2, Pdia3, Myh10, Pde2a, Adcy8 |
| IL-12 Signaling and Production in Macrophages | 4.57E -04 | Apoc2, Pon1, Il18, S100a8, Pik3r5, Prkch, Apoc4 |
| Antigen Presentation Pathway | 5.37E-04 | Hla-Drb5, Hla-Dmb, Pdia3, Psmb9 |
| Complement System | 5.37E-04 | Itgax, Cfd, C6, C3ar1 |
| Hepatic Fibrosis/Hepatic Stellate Cell Activation | 5.89E -04 | Mmp9, Myl4, Igfbp3, Col2a1, Myh10, Lep, Lepr, Timp2 |
| P2Y Purigenic Receptor Signaling Pathway | 1.38E-03 | Gng4, Pik3r5, Adcy2, Pdia3, Prkch, Adcy8 |
| Graft-versus-Host Disease Signaling | 1.45E-03 | Il18, Il1rn, Hla-Drb5, Hla-Dmb |
| Sperm Motility | 1.51E-03 | Pla2g2d, Atp1a4, Prkg2, Pdia3, Prkch, Pde2a |
| GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells | 1.70E-03 | Gng4, Adcy2, Pdia3, Prkch, Adcy8 |
| LPS/IL-1 Mediated Inhibition of RXR Function | 1.86E-03 | Il18, Apoc2, Gsto1, Il1rn, Fabp9, Slc27a3, Apoc4, Abcc3 |
| Relaxin Signaling | 2.63E-03 | Mmp9, Gng4, Pik3r5, Adcy2, Pde2a, Adcy8 |
| IL-8 Signaling | 2.88E-03 | Mmp9, Gng4, Pik3r5, Cstb, Itgax, Angpt1, Prkch |
| Clathrin-mediated Endocytosis Signaling | 2.95E-03 | Pon1, Apoc2, S100a8, Ubd, Pik3r5, Fgf18, Apoc4 |
| Thrombin Signaling | 3.55E-03 | Myl4, Gng4, Pik3r5, Adcy2, Pdia3, Prkch, Adcy8 |
| Nitric Oxide Signaling in the Cardiovascular System | 3.63E-03 | Adrb3, Prkg2, Pik3r5, Prkch, Pde2a |
*
IPA: ingenuity pathway analysis; p-value: Benjamini-Hochberg (BH) corrected p-value.