Table 5.
Pathway enrichment analysis of Dorsal Root Ganglia DEGs. Significantly enriched canonical pathways among the shared DEGs at all time points using IPA*
| Ingenuity Canonical Pathways | p-value | Genes |
|---|---|---|
| Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | 1.51E-03 | Sfrp5, F2rl1, Tlr7, Ccnd1, Il18rap, Lta, Prkcb, Pdia3, Il1r2, Frzb, Il6st, Pdgfc |
| Hepatic Fibrosis/Hepatic Cell Activation Stellate | 1.58E-03 | Agtr1b, Stat1, Il18rap, Il1r2, Lep, Myh8, Col13a1, Agtr1, Pdgfc |
| Tetrapyrrole Biosynthesis II | 2.09E-03 | Uros, Alas2 |
| Superoxide Radicals Degradation | 5.62E-03 | Gpx7, Nqo1 |
| Heme Biosynthesis II | 7.24E-03 | Uros, Alas2 |
| Retinol Biosynthesis | 1.23E-02 | Lrat, Esd, Lipg |
| Lanosterol Biosynthesis | 1.48E-02 | Lss |
| Chondroitin Sulfate Degradation (Metazoa) | 2.00E-02 | Chil3/Chil4, Mgea5 |
| The Visual Cycle | 2.00E-02 | Lrat, Rlbp1 |
| Neuroprotective Role of THOP1 in Alzheimer’s Disease | 2.09E-02 | Hla-A, Nfya, Mapt |
| Dermatan Sulfate Degradation (Metazoa) | 2.24E-02 | Chil3/Chil4, Mgea5 |
| S-methyl-5-thio-α-D-ribose 1-phosphate Degradation | 2.88E-02 | Apip |
| Formaldehyde Oxidation II (Glutathione-dependent) | 2.88E-02 | Esd |
| p70S6K Signaling | 3.09E-02 | F2rl1, Prkcb, Pdia3, Mapt, Agtr1 |
| GADD45 Signaling | 3.09E-02 | Ccnd1, Gadd45b |
| Protein Ubiquitination Pathway | 3.55E-02 | Usp1, Hspa1a/Hspa1b, HlaA, Usp54, Hsph1, Hspa4l, Usp18, Usp48 |
| Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 3.80E-02 | Tlr7, Lta, Oas2, Prkcb, Oas1b |
| UVA-Induced MAPK Signaling | 4.07E-02 | Stat1, Pdia3, Parp14, Smpd4 |
| Inosine-5′-phosphate Biosynthesis II | 4.37E-02 | Atic |
*
IPA: ingenuity pathway analysis; p-value: Benjamini-Hochberg (BH) corrected p-value.