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Representative 18F-TZ19106B microPET images of NHP brain. High striatum uptake at baseline was blocked by pretreatments with 1.0 or 2.0 mg/kg MP-10, a specific PDE10A inhibitor. In contrast, pretreatment with (−)-eticlopride even increased the striatal uptake of 18F-TZ19106B. All PET images are summed from 0 to 120 min.
