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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Cancer Res. 2018 Mar 20;78(10):2747–2759. doi: 10.1158/0008-5472.CAN-17-1900

Figure 2. KDM1A germline mutations in multiple myeloma patients.

Figure 2

A. Schematic of KDM1A protein. Germline mutations from Multiple Myeloma patients are shown on top. B–C. Quantile-quantile plots of gene-based burden tests for rare neutral synonymous variants (B) and rare predicted deleterious mutations (C). D. Quantile-quantile plot of MM case and control common variants. Lambda statistics are shown. E. KDM1A mRNA levels in normal plasma cells (NPC), MGUS and MM cells. *, p=7.45 × 10−6 (NPC-MGUS) and 1.70 × 10−5 (NPC-MM) respectively, moderated t-test. Mean and SEM bars are indicated.