A social interaction test was performed to reveal the effect of GluN3A on general social activity. A–D. We scored social sniffing, following, grooming, and total social time to quantify reciprocal social interaction. In this test, the trend of reduced social grooming in GluN3A mice was not statistically significant from WT mice. However, social following and social sniffing time, as well as the total social time, were significantly and markedly reduced in GluN3A KO mice compared to WT mice. Paired t test for A – C; Two-way ANOVA followed by Bonferroni correction: F(12,12)=1.516; *P<0.05 vs. WT; n=13 animals per group.