Figure 2.

Kinetic networks of inactive MOR macrostates within asymmetric and symmetric components. Asymmetric components C_0π (α₁ ≈ 0, α₂ ≈ π) and C_π0 (α₁ ≈ π, α₂ ≈ 0) are grouped together and shown in red while symmetric components C_ππ (α₁ ≈ π, α₂ ≈ π) and C₀₀ (α₁ ≈ 0, α₂ ≈ 0) are shown in yellow and purple, respectively. Each node represents a macrostate consisting of a group of PCCA clusters that are spatially and kinetically linked, and whose area is proportional to the probability of the state. The nodes are shaded according to the fraction of dimeric microstates (i.e., those characterized by a dimer population larger than 90%), with a solid color representing a fraction of 100%, and white signifying a fraction of 0%. These macrostates are further labeled according to the interfaces obtained from the contact map analysis of the dimeric microstates. The arrow thickness is proportional to the transition probability between the connected macrostates, ranging between ~3 × 10⁻⁵ (thinnest line) and 0.04 (thickest line). Representative configurations of the dimeric microstates are shown in cartoon models with the inter-protomeric variability within each macrostate captured by 100 randomly selected frames from that macrostate shown as gray clouds.