Table 2.
Parameter values obtained following application of the zero order, first order, Higuchi, Korsmeyer-Peppas, and Hixson-Crowell mathematical models to the curves for the release of CVC and LNL from the chitosan nanoparticles.
| Parameter | Zero order | First order | Higuchi | Korsmeyer-Peppas | Hixson-Crowell |
|---|---|---|---|---|---|
| NP_CVC | |||||
| Release constant (k) | 0.135 min−1 | 3.6 × 10−3 min−1 | 2.4 min−1/2 | 0.63 min−1 | 2.3 × 10−3 min−1 |
| Correlation coefficient (r) | 0.9695 | 0.8467 | 0.9966 | 0.9944 | 0.9776 |
| NP_LNL | |||||
| Release constant (k) | 0.242 min−1 | 4.6 × 10−3 min−1 | 4.29 min−1/2 | 0.79 min−1 | 9.6 × 10−3 min−1 |
| Correlation coefficient (r) | 0.9779 | 0.8312 | 0.9880 | 0.9701 | 0.8821 |