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. 2018 May 16;8:7688. doi: 10.1038/s41598-018-25984-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The new Ru(ƞ₆-p-cymene) complexes confers the polyQ-mediated proteotoxicity and other HD related functional deficits in C. elegans. (A) Complexes 3 and 4 significantly (P < 0.001) reduced the polyQ40::YFP aggregates in AM141 C. elegans. (B) Quantification of polyQ40::YFP aggregation. (C) Complexes 3 and 4 protect the polyQ-mediated death of ASH neurons. (D) Quantification of ASH neuronal survival. (E) Schematic overview for chemosensory behaviour assay. (F) Effects of complexes on chemosensory behaviour of HA759 C. elegans. Bar graphs are expressed as mean ± SEM of three independent experiments (n = 20~30 individuals/replicate). P values were calculated by Bonferroni post hoc test, ^n.s.not significant and **P < 0.001.