Table 3.
HLA class II haplotype frequencies among ASD patients and healthy controls.
| HLA classe II haplotype (DRB1-DQB1) |
ASD 455 subjects* % (n) |
HC 337 subjects* % (n) |
pc-value | OR (95%CI) |
|---|---|---|---|---|
| HLA-DRB1*11-DQB1*07 | 14.53 (69) | 8.7 (30) | 0,00172 | 1,75 (1,24–2,47) |
| HLA-DRB1*17-DQB1*02 | 9.22 (44) | 13.14 (46) | 0,00245 | 0,75 (0,53–1,04) |
| HLA-DRB1*04-DQBI*08 | 7.27 (35) | 9.77 (34) | 0,14624 | NS |
| HLA-DRB1*04-DQB1*02 | 0.42 (2) | 0.46 (2) | 0,16188 | — |
| HLA-DRB1*12-DQB1*07 | 1.29 (6) | 0.76 (3) | 0,20959 | — |
| HLA-DRB1*10-DBQ1*05 | 0.56 (3) | 0.91 (3) | 0,22171 | — |
| HLA-DRB1*15-DQB1*05 | 0.81 (4) | 0 (0) | 0,23538 | — |
| HLA-DRB1*07-DQB1*08 | 0 (0) | 0.78 (3) | 0,32001 | — |
| HLA-DRB1*15-DQB1*06 | 12.64 (60) | 10.24 (36) | 0,32672 | — |
| HLA-DRB1*14-DQB1*05 | 4.48 (21) | 3.51 (12) | 0,32891 | — |
| HLA-DRB1*13-DQB1*06 | 10.32 (49) | 11.92 (42) | 0,48848 | — |
| HLA-DRB1*09-DQB1*09 | 0.98 (5) | 0.76 (3) | 0,55949 | — |
| HLA-DRB1*07-DQB1*09 | 1.67 (8) | 1.52 (5) | 0,68934 | — |
| HLA-DRB1*16-DQB1*05 | 3.36 (16) | 2.59 (9) | 0,68999 | — |
| HLA-DRB1*04-DQB1*04 | 0.53 (3) | 0.61 (2) | 0,71389 | — |
| HLA-DRB1*13-DQB1*07 | 1.40 (7) | 1.37 (5) | 0,72218 | — |
| HLA-DRB1*04-DQB1*07 | 4.08 (19) | 4.58 (16) | 0,8153 | — |
| HLA-DRB1*07-DQB1*02 | 10.64 (51) | 10.84 (38) | 0,82915 | — |
| HLA-DRB1*01-DQB1*05 | 8.96 (43) | 10.70 (38) | 0,88199 | — |
| HLA-DRB1*08-DQB1*04 | 2.10 (10) | 2.90 (10) | 0,92928 | — |
*Among the total of 474 ASD patients and 350 HC subjects, only reliable haplotype assignment by maximum likelihood estimates of haplotype probabilities are herein reported (for ASD: 455 and for HC: 337 subjects). NS: statistically non significant.