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. 2018 May 16;8:7628. doi: 10.1038/s41598-018-25743-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Up-regulated miRNA vs. down-regulated mRNA pairs. (A) 114 up-regulated miRNA vs. down-regulated mRNA pair regulatory networks with 6 miRNAs and their targets. Ellipse nodes represent miRNAs, and diamond nodes represent mRNAs; up-regulated and down-regulated miRNAs are shown in red and green, respectively. (B) A sub-network of Abcg8, Cyp1a1 and Tmem255a, each connected to 5 different miRNAs. (C) Venn diagram of miR-200b-3p, miR-200b-5p and miR-200c-3p. (D) A sub-network of miR-200b-3p, miR-200b-5p and miR-200c-3p and their target genes. The blue label represents the intersection target genes of the three miRNAs. (E) GO analysis of miR-200b-3p, miR-200b-5p and miR-200c-3p target genes; the x-axis represents gene counts, and the y-axis represents GO terms. (F) KEGG pathway analysis of miR-200b-3p, miR-200b-5p and miR-200c-3p target genes; the x-axis represents gene counts, and the y-axis represents KEGG pathway names.