Figure 5.

Computational models of Shab ion channel activity describe their differing kinetics. Fitting the electrophysiological data (see Fig. 1) to classical Hodgkin-Huxley equations generated parameters that describe the behaviors (B). These descriptions match well with experimental data acquired (A). The hKv9.2 subunits activate at more negative values (activation Vh) as seen in the experimental data. The extent of inactivation is higher in the mutant hKv9.2-D379E as evidenced by the lower inactivation K. The speed of inactivation is also higher in the mutant hKv9.2-D379E as shown by the higher inactivation σ.