Table 4.
Association of factor XIII (FXIII) levels during thrombolysis with short-term functional outcomes.
| Favorable outcome (n = 51) | No change (n = 42) | Unfavorable outcome (n = 16) | Death* (n = 4) | Intracerebral hemorrhage (n = 13) | P-value† death vs. all other outcomes | P-value†,‡ death vs. all other outcomes | |
|---|---|---|---|---|---|---|---|
| Before thrombolysis (A) | |||||||
| FXIII activity (%) | 127.3 ± 35.2 | 128.2 ± 41.1 | 128.1 ± 26.3 | 100.0 ± 28.7 | 125.2 ± 36.9 | 0.129 | 0.340 |
| FXIII-A2B2 (mg/l) | 22.9 ± 8.9 | 22.4 ± 7.7 | 22.7 ± 4.4 | 18.3 ± 5.5 | 21.6 ± 5.99 | 0.165 | 0.416 |
| Immediately after thrombolysis (B) | |||||||
| FXIII activity (%) | 123.1 ± 33.2 | 130.1 ± 35.9 | 123.3 ± 31.9 | 111.3 ± 18.8 | 119.3 ± 38.4 | 0.256 | 0.596 |
| FXIII-A2B2 (mg/l) | 21.2 ± 6.5 | 22.4 ± 7.8 | 20.3 ± 5.5 | 20.1 ± 4.2 | 20.8 ± 7.8 | 0.335 | 0.702 |
| 24 hours after thrombolysis (C) | |||||||
| FXIII activity (%) | 115.8 ± 28.2 | 122.0 ± 40.6 | 116.0 ± 33.8 | 60.0 ± 28.9 | 119.9 ± 40.4 | 0.003 | 0.009 |
| FXIII-A2B2 (mg/l) | 20.0 ± 5.3 | 19.9 ± 7.6 | 19.5 ± 5.8 | 9.7 ± 5.3 | 19.1 ± 6.9 | 0.006 | 0.014 |
Short-term functional outcomes were assessed at 7 days post-event. Results are expressed as mean ± standard deviation. n, number; favorable outcome: a decrease in NIHSS score by at least 4 points or to 0 by day 7; no change: a change in NIHSS score less than 4 points by day 7; unfavorable outcome: an increase in NIHSS score by at least 4 points by day 7; *stroke-associated death excluding death due to intracerebral hemorrhage; †ANOVA with Bonferroni post hoc test; ‡adjusted to age and sex in the statistical model.