Table 1.
Patients’ characteristics
| Characteristic | All patients N = 110 (100%) | FUP ≥ day 14 and no AKI day 2–14 N = 39 (35%) | FUP ≥ day 14 and AKI day 2–14 N = 63 (57%) | p valuea |
|---|---|---|---|---|
| Age (year) | 47 (13) | 47 (12) | 47 (14) | 0.88 |
| Male | 74 (67%) | 28 (72%) | 40 (63%) | 0.39 |
| ICM | 38 (35%) | 19 (49%) | 15 (24%) | 0.01 |
| DM | 6 (5.5%) | 1 (2.6%) | 5 (7.9%) | 0.40 |
| VAD preoperative | 55 (50%) | 21 (54%) | 31 (49%) | 0.65 |
| Surgery time > 400 min | 34 (31%) | 6 (15%) | 25 (40%) | 0.01 |
| ECMO postoperative | 7 (6.4%) | 2 (5.1%) | 4 (6.3%) | 1.00 |
| Death day 1–14 | 4 (3.6%) | 0 (0%) | 0 (0%) | b |
| Death day 1–1 year | 8 (7%) | 1 (3%) | 3 (5%) | 1.00 |
| At least once during day 1–6 | ||||
| Liver injury | 49 (45%) | 13 (33%) | 30 (48%) | 0.16 |
| Anemia | 107 (97%) | 38 (97%) | 62 (98%) | 1.00 |
| Hypo-albuminemia or too low total protein concentration | 38 (35%) | 12 (31%) | 21 (33%) | 0.79 |
| Supratherapeutic whole-blood tacrolimus trough concentration | 37 (34%) | 13 (33%) | 21 (33%) | 1.00 |
| SIRS | 107 (97%) | 37 (95%) | 62 (98%) | 0.56 |
| Shock | 92 (84%) | 32 (82%) | 55 (87%) | 0.47 |
| At least one drug increasing tacrolimus concentration | 104 (95%) | 36 (92%) | 60 (95%) | 0.67 |
| At least one drug decreasing tacrolimus concentration | 85 (77%) | 38 (97%) | 52 (83%) | 0.32 |
| Nephrotoxic drugs other than tacrolimus | 104 (95%) | 38 (97%) | 58 (92%) | 0.40 |
Values are presented as n (%), except for age, which are mean (SD)
a Chi square test, Fisher’s exact test or t test was used, where appropriate
b No statistics could be computed because no death occured
AKI acute kidney injury, min minute, ICM ischemic cardiomyopathy, DM diabetes mellitus, VAD ventricular assist device, ECMO extracorporeal membrane oxygenation, SIRS systemic inflammatory response syndrome, SD standard deviation