Table 2.
GEE analyses to test the variables influencing AKI
| Variable | Day 2–6a, c | Day 2–14b, d | ||
|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | |
| Supratherapeutic whole-blood tacrolimus trough concentration | 1.66 | 1.20–2.31 | 2.10 | 1.35–3.25 |
| SIRSe | 1.29 | 0.96–1.75 | NA | NA |
| Shocke | 1.24 | 0.91–1.67 | NA | NA |
| Nephrotoxic drugse | NA | NA | ||
| 1 nephrotoxic drug | 1.28 | 0.74–2.23 | NA | NA |
| 2 nephrotoxic drugs | 1.07 | 0.60–1.91 | NA | NA |
| ≥3 nephrotoxic drugs | 1.02 | 0.57–1.83 | NA | NA |
| ICM | 2.23 | 0.97–5.11 | 1.29 | 0.58–2.83 |
| DM | 1.72 | 0.38–7.77 | 1.97 | 0.57–6.83 |
| VAD pre-transplantation | 0.36 | 0.15–0.86 | 0.50 | 0.24–1.04 |
| ECMO post-operation | 2.73 | 0.77–9.68 | 3.02 | 0.95–9.63 |
| Surgery time > 400 min | 2.56 | 1.03–6.36 | 2.66 | 1.27–5.58 |
| Age (years) | 1.00 | 0.97–1.03 | 1.00 | 0.97–1.03 |
| Contrast | 0.76 | 0.28–2.01 | 0.75 | 0.31–1.78 |
aDay 2–day 6: data concerning day 2 up to day 6
b Day 2–day 14: data concerning day 2 up to day 14
c Day 2–day 6: estimate of the intercept: − 2.9593
d Day 2–day 14: estimate of the intercept: − 2.82
e Data not available between day 7 and day 14
GEE generalized estimating equation, AKI acute kidney injury, OR odds ratio, CI confidence interval, SIRS systemic inflammatory response syndrome, ICM ischemic cardiomyopathy, DM diabetes mellitus, VAD ventricular assist device, ECMO extracorporeal membrane oxygenation, min minute