Table 4.

Univariate and multivariate analysis of factors affecting 5-year overall and disease-free survival

Factors	Overall survival			Disease-free survival
	Univariate	Multivariate		Univariate	Multivariate
	p	HR (95% CI)	p	p	HR (95% CI)	p
Age (≥ 60 years)	< 0.001	2.225 (1.723–2.873)	< 0.001	0.007	1.458 (1.149–1.852)	0.002
Male	0.378			0.205
BMI (≥ 25)	0.289			0.515
ASA score 3–4	0.617			0.373
Adjuvant CTx	< 0.001	0.816 (0.648–1.027)	0.083	0.637
Retrieved LNs ≥ 12	0.149			0.425
Open approach	< 0.001	3.920 (2.754–5.580)	< 0.001	0.001	1.726 (1.344–2.216)	< 0.001
Transfusion (+)	0.382			0.039	2.280 (1.513–3.436)	< 0.001
TNM stage III	< 0.001	2.975 (2.355–3.757)	< 0.001	< 0.001	3.918 (3.064–5.012)	< 0.001
Lymphatic invasion	0.010	2.457 (1.385–4.360)		< 0.001	2.942 (2.334–3.708)	< 0.001
Perineural invasion	0.293			0.002	2.657 (1.965–3.593)	< 0.001
Vascular invasion	0.002	2.967 (2.237–3.935)	< 0.001	0.004	3.346 (2.537–4.412)	< 0.001