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. 2018 May 16;8:7687. doi: 10.1038/s41598-018-25804-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fluorescence microscopy of MPO activity. The images show 5HT-Cy3 staining of MPO – positive cells. 5HT-Cy3 (red fluorescence) detects the presence of active MPO enzyme. (A) The infiltration of MPO+ neutrophils from the vascular lumen of human unruptured hBA; (B) MPO in cells infiltrated in AVM (magnification – 10x); (C) AVM sample showing intracellular and extracellular MPO at high magnification (40x), L- vascular lumen; (D) high-magnification image of infiltrating neutrophils in unruptured hBA (see panel A) by using MPO and anti-calprotectin (S100A8/A9 complex) detection (63x); (E) - high-magnification image of infiltrating neutrophils in AVM (see panel C) by using MPO and calprotectin detection. Red- 5HT-Cy3, green - anti-calprotectin antibody, blue - DAPI. Bars (D,E) = 25 µm.