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. 2018 May 16;8:7735. doi: 10.1038/s41598-018-25462-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) V_R:D distribution for missense variants in CGC and non-CGC genes. (b) Correlation between V_R:D and expression change log2[T/N] (Spearman, r_s), of missense variants in the entire dataset and in the CGC subset only (c). (d) V_R:D distribution for silent variants between CGC and non-CGC genes was similar (p = 0.81). (e) Correlation between V_R:D and log2[T/N] in the entire set of silent variants, and for those positioned in CGC genes only (f).