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. 2018 May 16;8:7735. doi: 10.1038/s41598-018-25462-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) V_R_:D distribution for somatic variants that generate a new TFBS (TFBS-gain) as compared to those that disturb an existing TFBS (TFBS-loss). (b) Correlation between log2[T/N] and V_R:D TFBS-gain variants, and in TFBS-loss variants (c). (d) Distribution of V_R:D between TFBS-gain and TFBS-loss somatic variants in non-CGC genes; no difference was observed. (e) Correlation between log2[T/N] and V_R:D in TFBS-gain variants in the CGC genes, and in the non-CGC genes (f).