Table 2. Clinical characteristics and ovarian stimulation outcomes in women with antiphospholipid antibody (APA)-positive and -negative group.
| Characteristics | APA-positive group (n=12) | APA-negative group (n=181) | P | |
|---|---|---|---|---|
| Age of women (yr) | 34 (33–38) | 35 (33–37) | NS | |
| Body mass index (kg/m2) | 21.4 (19.5–23.5) | 21.5 (20.1–23.6) | NS | |
| Parous | 0 | 12 | NS | |
| Indications for IVF | NS | |||
| Unexplained | 2 | 75 | ||
| Tubal | 5 | 49 | ||
| Ovulatory | 0 | 6 | ||
| Old age | 2 | 17 | ||
| DOR | 2 | 19 | ||
| Endometriosis | 0 | 14 | ||
| Multiple factors | 1 | 16 | ||
| Serum AMH level (ng/mL) | 3.8 (2.1–8.1) | 2.8 (1.4–5.2) | NS | |
| Titers of APA | ||||
| Lupus anticoagulant – screening | 39.3 (36.1–48.7) | 37.3 (37.0–38.7) | NS | |
| Lupus anticoagulant – confirmative | 1.5 (−1.7–4.6) | 1.1 (0.1–1.2) | NS | |
| Anticardiolipin antibody IgG | 4.0 (2.7–5.5) | 3.0 (3.5–4.3) | NS | |
| Anticardiolipin antibody IgM | 18.0 (6.0–43.4) | 7.0 (7.0–8.3) | 0.001 | |
| Anti-β2-glycoprotein 1 antibody IgG | 0.1 (−3.9–19.1) | 0.1 (0.1–0.5) | NS | |
| Anti-β2-glycoprotein 1 antibody IgM | 1.1 (−1.7–13.3) | 0.5 (0.9–1.5) | NS | |
| Pituitary suppression | NS | |||
| GnRH agonist | 6 | 101 | ||
| GnRH antagonist | 6 | 80 | ||
| Dose of gonadotropin (ampule) | 34 (22–42) | 34 (27–44) | NS | |
| No. of retrieved oocytes | 16 (8.5–22.0) | 10 (7–14) | 0.044 | |
| No. of retrieved mature oocytes | 9.5 (4.5–14.5) | 8 (5–11) | NS | |
| No. of fertilized oocytes | 9 (5–13) | 6 (4–10) | NS | |
| Triple pattern endometrium | 4 | 77 | NS | |
| No. of transferred embryos | ||||
| Overall | 2 (2–2) | 2 (2–2) | NS | |
| Day 2–4 transfer | 2 (2–2) | 2 (2–2) | NS | |
| Day 5 transfer | 2 (2–2) | 2 (2–2) | NS | |
Data shown are median (95% confidence interval). Mann-Whitney U test, χ2 or Fisher's exact test.
NS, not significant; IVF, in vitro fertilization; DOR, diminished ovarian reserve; AMH, anti-Müllerian hormone; GnRH, gonadotropin releasing hormone.