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. 2018 Jan 26;32(6):3070–3084. doi: 10.1096/fj.201700464R

Figure 11.

Figure 11.

Loss of BRCA1 does not affect Parkin or Drp1 phosphorylation in skeletal muscle. A, B) No significant differences were detected in GLUT4 protein content in the TA muscle from age-matched WT and BRCA1KOsmi mice that were fed normal CD or HFD. B) No significant differences were detected in HKII protein content in the TA muscle from age-matched WT and BRCA1KOsmi mice that were fed a CD or an HFD. C) PFK protein content was elevated in WT and KO exposed to an HFD. +, Main effect of diet, P ≤ 0.05. WT-CD vs. KO-CD exhibited a trend toward statistical significance. P = 0.060. D) LDH protein content was higher in WT and KO fed to an HFD. +, Main effect of diet. P ≤ 0.05. WT-CD vs. KO-CD almost reached statistical significance (n = 4–6 mice/group). P = 0.065. E) Examples of bands measured from the Western blots from each target in each group. Noncontiguous bands are shown in the examples.