Figure 8.
Safety profiles after daily administration of chloride derivatives by IP injection in male BALB/c mice for 28 d. A) Body weights of mice injected with vehicle, 0.2 mg CL-4, or 0.2 mg CL-5 for the course of the experiment. B) H&E staining of retinas harvested at d 28 of injections. C, D) In vivo OCT images (C) and quantified ONL thickness (D) of retinal cross-sections imaged at d 26 of injections. E, F) Representative ERG traces (E) and quantified a- and b-wave amplitudes (F) measured at d 28 of injections. ONH, optical nerve head. Error bars, ±sd.