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Acer2 knockout reduces SPH and S1P levels in lungs, but not in the colon, lymph nodes, or thymus. A) Quantitative PCR analysis for Acer2 mRNA levels in major organs in WT mice at age 6 wk. B–D) LC-MS/MS analysis for sphingolipid levels in lungs (B), lymph nodes (C), or spleen (D) in Acer2+/+ or Acer2−/− male mice at age 6 wk. Cer, ceramide; dhCer, dihydroceramide; MNE, mean normalized expression; Pr, protein. Data represent means ± sd (n = 3 mice/genotype).
