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Knocking out Acer1 or Acer3 does not further reduce SPH and S1P levels in Acer2 knockout mice. Whole blood samples were collected into EDTA-coated tubes from Acer1+/+Acer2+/+, Acer1+/+Acer2−/−, Acer1−/−Acer2+/+, Acer1−/−Acer2−/−, Acer2+/+Acer3+/+, Acer2+/+Acer3−/−, Acer2−/−Acer3+/+, and Acer2−/−Acer3−/− mice at age 6 wk and subjected to LC-MS/MS analysis for SPH (A) or S1P levels (B). Data represent means ± sd (n = 3 mice/genotype).
