Figure 7.
Immune Signatures and Response to BEV
(A) Mean T effector/T cell gene expression values (plotted as log2, x axis) were correlated with CD8 immunoreactivity (plotted as log10, y axis) for 18 cases. Two cases were scored as 0% by immunohistochemistry and were not plotted (expression values −7.37 and −7.58).
(B) Gene expression signatures for CD8 T effector and T cells plotted as a heatmap from 20 cases with RNA-seq data. Hypermutator cases and those with MAPK alterations including NF1, FGFR1, or NTRK2 are annotated.
(C) Plot of T effector/T cell gene expression values in MAPK-altered samples compared with those without. Horizontal bar represents the mean, error bars the SD.
(D) Kaplan-Meier plot of event-free and overall survival of 36 cases (y axis) treated with TMZ/RT, separated by levels of CD8+ T cells, time given in months (x axis), and p value calculated by the log rank test.
(E) Kaplan-Meier plot of event-free and overall survival of 34 cases (y axis) treated with TMZ/RT plus BEV, separated by levels of CD8+ T cells, time given in months (x axis), and p value calculated by the log rank test.
See also Figures S6 and S7 and Table S5.