Table 3.
The rotavirus vaccination cauliflower toolbox used in a mature healthcare market: data entry [29,31,40,41].
| Cauliflower floret number |
% per year | Unit cost (€) | QALY loss/day | VE (%) | Duration (days) | ||
|---|---|---|---|---|---|---|---|
| Cohort | 10,000 | ||||||
| 1a | VE | Cases | 40% | 60% | |||
| Medical visits | 15% | 75% | |||||
| Hospitalisations | 3% | 82% | |||||
| Deaths | 0.001% | 85% | |||||
| 1b | Subject | Cases | 40% | −0.05 | 6 | ||
| Medical visits | 15% | −0.10 | 3 | ||||
| Hospitalisations | 3% | −0.25 | 4 | ||||
| Deaths | 0.001% | −1.00 | 365 | ||||
| QALY | €25,000 | ||||||
| 1c | Direct cost | Cases | 40% | ||||
| Medical visits | 15% | €25 | |||||
| Hospitalisations | 3% | €2,300 | |||||
| Deaths | 0.001% | ||||||
| Vaccine | 86% | €75 | |||||
| 2a | Indirect vaccine effect | Cases | 40% | +15% | |||
| Medical visits | 15% | +10% | |||||
| Hospitalisations | 3% | +10% | |||||
| Deaths | 0.001% | +10% | |||||
| 2b | Caregiver | Cases | 40% | −0.01 | 6 | ||
| Medical visits | 15% | −0.05 | 3 | ||||
| Hospitalisations | 3% | −0.10 | 4 | ||||
| Deaths | 0.001% | −0.30 | 365 | ||||
| QALY | €25,000 | ||||||
| 2c | Indirect cost | Cases | 40% | ||||
| Working mothers | 30% | ||||||
| Cost per day lost | €135 | 4 | |||||
| 3a | QoC | Extra investment | +4 beds | €250,000 | |||
| Hospitalisations | 2% | ||||||
| Deaths | 0.0005% | ||||||
QALY, quality-adjusted life-year; VE, vaccine efficacy; QoC, quality of care