Table 3.
Absolute event rates, absolute risks, and univariable and multivariable hazard ratios for symptomatic intracranial haemorrhage and recurrent ischaemic stroke during follow-up, according to baseline presence and burden of cerebral microbleeds
| Absolute event rate* | Rate per 1000 patient-years (95% CI) | Absolute rate increase per 1000 patient-years (95% CI) | Univariable hazard ratio (95% CI) | Adjusted hazard ratio (95% CI)† | ||
|---|---|---|---|---|---|---|
| Symptomatic intracranial haemorrhage | ||||||
| No cerebral microbleeds | 7/2654 | 2·6 (1·1 to 5·4) | 1 (ref) | 1 (ref) | 1 (ref) | |
| Cerebral microbleeds present | 7/712 | 9·8 (4·0 to 20·3) | 7·2 (2·9 to 14·9) | 3·73 (1·31 to 10·64) | 3·67 (1·27 to 10·60) | |
| 1 cerebral microbleed | 2/367 | 5·4 (0·7 to 19·7) | 2·8 (−0·4 to 14·3) | 2·04 (0·42 to 9·84) | 2·03 (0·42 to 9·83) | |
| ≥2 cerebral microbleeds | 5/345 | 14·4 (4·7 to 33·8) | 11·8 (3·6 to 28·4) | 5·58 (1·77 to 17·58) | 5·46 (1·70 to 17·51) | |
| Recurrent ischaemic stroke | ||||||
| No cerebral microbleeds | 39/2608 | 15·0 (10·6 to 20·4) | 1 (ref) | 1 (ref) | 1 (ref) | |
| Cerebral microbleeds present | 17/704 | 24·1 (14·1 to 38·7) | 9·1 (3·5 to 18·3) | 1·62 (0·92 to 2·87) | 1·53 (0·85 to 2·76) | |
| 1 cerebral microbleed | 9/362 | 24·9 (11·4 to 47·2) | 9·9 (0·8 to 32·2) | 1·68 (0·82 to 3·47) | 1·75 (0·84 to 3·65) | |
| ≥2 cerebral microbleeds | 8/341 | 23·4 (10·1 to 46·2) | 8·4 (−0·5 to 25·8) | 1·56 (0·73 to 3·35) | 1·32 (0·60 to 2·93) | |
Data are calculated on the 1447 participants with follow-up data available.
*
Calculated as number of events/patient-years.
†
Adjusted for age and hypertension for symptomatic intracranial haemorrhage, and adjusted for age, sex, hypertension, diabetes, previous ischaemic stroke, and age-related white matter hyperintensities score for recurrent ischaemic stroke.