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. 2018 May 16;20:40. doi: 10.1186/s13058-018-0968-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Circulating ESR1 mutation frequency during HR+ breast cancer history. At the end of adjuvant treatment by AI, circulating ESR1 mutations were not detected among the 42 patients of this cohort. At relapse, 2/38 patients (5.3%) had a detectable circulating ESR1 mutation. At progression after re-exposure to AI as first-line metastatic treatment, 7/21 patients (33%) had a detectable circulating ESR1 mutation. AI aromatase inhibitor, CT chemotherapy, RT radiation therapy