Supplementary Table 1.
Main functions: surfactant delivery and epithelial repair
| Function/product | Functional significance | Reference |
| Surfactant | ||
| Synthesis | ||
| Components of surfactant | ||
| Phospholipids | Surface activity | [186] |
| Surfactant proteins | ||
| A | Tubular myelin formation | [71,187,188] |
| Defence | [33] | |
| B | Absorption of lipid to monolayer | [71,189] |
| C | [86] | |
| D | Defence | [34,190] |
| Components secreted together with surfactant | ||
| Lysozyme | Defence | [35,191] |
| Plasmalogens | Protection against oxidation | [192] |
| Cathepsin H | ||
| Maturation | ||
| Intracellular cathepsin H | Processing of SP-B | [194] |
| Processing of SP-C | [50] | |
| Secretion | ||
| Signal receptors | ||
| β-adrenergic receptors | [195,196] | |
| P1 purinoreceptors | [197,198] | |
| P2Y purinoreceptors | [198,199] | |
| Components of exocytosis apparatus | ||
| Microtubules | [65] | |
| Actin | [66] | |
| Annexin II | [200] | |
| Annexin IV | [201] | |
| Annexin VII (= Synexin) | [202,203] | |
| Extracellular transformation | ||
| α1-antitrypsin | [2048] | |
| Convertase | Conversion of lipid monolayer into vesicles | [88,89,205] |
| Recycling | ||
| Receptor of SP-A | [206] | |
| Lamellar body lysosomal enzymes | ||
| Alkaline phosphatase | Marker of type II cells | [207] |
| α-glucosidase | [208] | |
| α-mannose | [208] | |
| Alveolar epithelial repair | ||
| Proliferation | ||
| Cyclin A | [209] | |
| Cyclins D1, D2 | Proliferation, differentiation | [210] |
| Cyclin dependent phosphokinases | Proliferation, differentiation | [210] |
| PTHRP | Inhibition of proliferation | [211] |
| Calmodulin | Proliferation, differentiation | [212,213] |
| Insulin-like growth factor (IGF)-binding protein2 | G1-arrest | [214] |
| Differentiation | ||
| Retinoic acid receptor | Inhibition of differentiation | [215] |
| Aminopeptidase N | [216] | |
| Apoptosis | ||
| CD95 (receptor of Fas-ligand) | [134] | |
| Fas-ligand | [138] | |
| Bax | Pro-apoptotic peptide | [217] |
| Bcl-2 | Anti-apoptotic peptide | [138] |
| Caspase-3 | Execution caspase | [138] |