Fluid and electrolyte balance |
|
|
Water channels
|
|
|
Aquaporin 1 |
|
[218] |
Aquaporin 5 |
|
[219] |
Hg-insensitive channel (MIWC) |
|
[220] |
Hg-sensitive channel (CHIP28) |
|
[221] |
Ion channels
|
|
|
H+-channel |
|
[222] |
Na+-channel |
|
[223] |
Cl--channel |
|
[224] |
Ion pumps
|
|
|
H+-pump |
pH of hypophase fluid |
[30] |
Cl-/HCO3-anion exchanger |
In vitro |
[225] |
Na+/H+-ion exchanger |
|
[226] |
Na+/K+-atpase |
Membrane potential |
[223,227,228] |
Others
|
|
|
Protein clearance |
|
[229] |
Carbanhydrase II |
|
[230] |
Components of innate defence |
|
|
Surfactant components
|
|
|
SP-A |
|
[32,33] |
SP-D |
|
[34,190] |
Lysozyme |
|
[35,191] |
Antigen presentation
|
|
|
MHC class II |
Human (adult, foetal) |
[231,232] |
|
IFN-stimulation |
[171] |
HLA class I |
IFN-stimulation |
[233] |
Fc-receptor |
Cell line A549, not present in vivo
|
[234] |
CD80, CD86 |
|
[234] |
Complement complex
|
|
|
C2, C3, C4, C5 |
|
[235] |
Antiproteases
|
|
|
α1-antitrypsin |
|
[236,237] |
Elafin |
Cell line A549 |
[238] |
Matrix metalloproteinase (MMP) |
|
[239] |
MMP-inhibitors (TIMP) |
|
[239] |
Oxidants
|
|
|
NAD(P)H-oxidase |
|
[240] |
Superoxide anion, hydrogen peroxide |
|
[240] |
Antioxidants
|
|
|
Glutathione |
|
[241] |
γ-glutamyl transferase |
|
[242] |
Plasmalogens |
Protection of surfactant |
[192] |
Mn superoxide dismutase (SOD) |
In vitro |
[243] |
Mn-, Cu-, Zi-SOD |
In vitro |
[244] |
Metabolism of Xenobiotics
|
|
|
Cytochrome P-450 mono-oxygenase |
|
[245] |
Coagulation/fibrinolysis |
|
|
Fibrinogen |
|
[246] |
Urokinase-type plasminogen activator (uPA) |
|
[247] |
UPA receptor |
IL-1β stimulation |
[248] |
Plasminogen activator inhibitor (PA-I) |
|
[247,249] |
Tissue factor |
In bleomycin-induced injury |
[249,250] |
Cytokines/receptors |
|
[251] |
Cytokines
|
|
|
GM-CSF |
In vitro |
[165] |
IL-1β |
Upon interaction with particles |
[252] |
IL-4 |
Human, interstitial lung disease |
[253] |
IL-6 |
Upon interaction with particles |
[252] |
IL-8 |
IL-1, TNF-α stimulation |
[254,255,256] |
IL-11 |
In vitro |
[257] |
Interferon-γ |
Human, interstitial lung disease |
[253] |
MCP-1 |
In vitro |
[258] |
RANTES |
After TNF-α stimulation |
[173] |
Tumour necrosis factor (TNF)-α |
Hyperplastic type II cells |
[259,260] |
Cytokine receptors
|
|
|
IL-2-receptor |
In vitro |
[261] |
TNF-receptor |
In vitro |
[262] |
Lymphotoxin-β-receptor |
Hyperplastic type II cells |
[263] |
Growth factors/receptors |
|
|
Growth factors
|
|
|
Epidermal growth factor (EGF) |
In vitro |
[264] |
IGF-II |
|
[214] |
Platelet derived growth factor (PDGF) |
Idiopathic lung fibrosis |
[182] |
TGF-α |
|
[265] |
TGF-β |
Hyperplastic type II cells |
[266] |
TGF-β1
|
Hyperplastic type II cells |
[267] |
TGF-β3
|
Normal type II cells |
[268] |
Vascular endothelial growth factor (VEGF) |
|
[269] |
Growth factor receptors
|
|
|
Basic fibroblast growth factor-receptor |
|
[270] |
EGF-receptor |
|
[271] |
Hepatocyte growth factor-receptor |
|
[162] |
KGF-receptor |
During ontogenesis |
[272,273] |
IGF-receptor-1 |
Early postnatal phase |
[274] |
IGF-receptor-2 |
|
[214] |
Components of cell–cell interaction |
|
|
Gap junction proteins
|
|
|
Connexin 43 |
Electric, ionic coupling |
[142] |
Adhesion molecules
|
|
|
CD44s, CD44v |
|
[275] |
Ep-Cam |
|
[146] |
E-cadherin |
|
[276] |
ICAM-1 |
After TNF-α stimulation |
[173,277] |
VCAM-1 |
After TNF-α stimulation |
[173] |
Integrins
|
|
|
α6 β1
|
In vitro |
[278] |
α3 β1
|
In vitro |
[278] |
Paracrine-acting molecules
|
|
|
Endothelin-1 |
Human |
[279] |
Endothelin receptor A |
Rat cell line L2 |
[159] |
Prostaglandin E-2 |
|
[280] |
Prostacyclin |
|
[280] |
Nitrogen oxide (NO) |
In vitro |
[281,282] |
Constitutive NO synthase |
Human cell line A859 |
[283] |
Inducible NO synthase |
In vitro, rat cell line L2 |
[281,284] |
Components of extracellular matrix |
|
|
Entactin |
Basal membrane, in vitro
|
[285] |
Laminin |
Basal membrane, in vitro
|
[278] |
Fibronectin |
In vitro |
[286,287] |
Tenascin |
Early organogenesis |
[288] |
|
Hyperplastic type II cells |
[289] |
Proteoglycans |
In vitro |
[290] |
Collagen type IV |
|
[291,292] |