Table 2.
Subtest characteristics: ICC's, score ranges, and mean scores in the patient and control group
| Measure | Total group |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ICCs | Score range | Patients |
Controls |
|||||||
| Baseline (SD) | Retest (SD) | P value | Cohen's d | Baseline (SD) | Retest (SD) | P value | Cohen's d | |||
| ADAS-Cog Word Recognition | .70 | 0–12 | 4.6 (2.8) | 4.8 (3.1) | .684† | .07 | 1.2 (1.3) | 0.7 (1.1) | .097† | .40 |
| ADAS-Cog Orientation | .72 | 0–4 | 1.1 (1.3) | 1.2 (1.3) | .728† | .08 | 0.0 (0.2) | 0.1 (0.3) | .564† | .12 |
| COWAT (DAT/FAS, 60 sec) | .85 | 4–69 | 31.7 (13.3) | 33.7 (14.4) | .067∗ | .15 | 42.9 (10.6) | 45.4 (8.7) | .012† | .26 |
| CFT (animals, 60 sec) | .83 | 4–35 | 13.7 (5.7) | 14.4 (5.7) | .260∗ | .12 | 24.2 (5.0) | 25.3 (4.7) | .185∗ | .23 |
| DSST (90 sec) | .93 | 3–73 | 31.1 (11.7) | 33.5 (11.4) | .005∗ | .21 | 52.4 (9.6) | 55.2 (11.0) | .011∗ | .28 |
| DSB | .72 | 2–12 | 5.5 (1.5) | 5.5 (2.0) | .561† | .04 | 6.7 (1.6) | 7.2 (2.0) | .081∗ | .28 |
| ADAS-Cog Word Recall | .89 | 0–9 | 5.6 (1.5) | 5.8 (1.4) | .192† | .14 | 2.5 (1.22) | 2.7 (1.2) | .141† | .17 |
| A-IADL-Q | .96 | 22.8–76.0 | 49.7 (10.4) | 49.8 (10.4) | .830∗ | NA | 71.2 (4.8) | 71.8 (3.7) | .432∗ | NA |
| Overall CFC score | .95 | −14.9 to 12.36 | −3.9 (4.3) | −3.7 (4.3) | .412∗ | NA | 5.7 (2.4) | 6.6 (2.7) | .006∗ | NA |
Abbreviations: ADAS-Cog, Alzheimer's Disease Assessment Scale–cognitive subscale; ICC, intraclass correlation coefficient; SD, standard deviation; COWAT, Controlled Oral Word Association Test; CFT, Category Fluency Test; DSST, Digit Symbol Substitution Test; DSB, Digit Span backward; A-IADL-Q, Amsterdam Instrumental Activities of Daily Living Questionnaire; CFC, cognitive-functional composite; NA, not assessed for this score.
∗
Tested using paired-samples t-test.
†
Tested using Wilcoxon rank-sign test.