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. Author manuscript; available in PMC: 2018 Sep 14.
Published in final edited form as: J Med Chem. 2017 Aug 28;60(17):7459–7475. doi: 10.1021/acs.jmedchem.7b00805

Figure 7.

Figure 7

Effects of 1a, 1c, and 3a on STZ-induced diabetic mice. STZ-induced diabetic male C57BL/6J mice were orally administered potential antidiabetic drugs at 20 mg/kg for 5 days. Eight mice were used in each group. Glibenclamide was used as a positive control. Serum glucose (A), triglyceride (B), and lactate (C) levels were measured. Results are the mean ± SD of three independent experiments. Statistical analyses were performed using one-way ANOVA followed by Tukey’s post-test. (D) Serum glucose concentrations were measured just before drug administration (0 h) and at 1 and 4 h after drug administration. Each symbol represents the mean ± SD of the difference in the time spent after the drug or vehicle treatments (8 animals per each group): (*) p ≤ 0.05 and (**) p ≤ 0.01, significantly different from the vehicle-treated STZ-induced diabetic mouse group.