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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Inorg Biochem. 2018 Jan 4;180:186–193. doi: 10.1016/j.jinorgbio.2017.12.016

Table 1.

IC50 values for disulfide prochelators in breast cancer cell lines and normal lung fibroblastsa

IC50 (μM)
MDA-MB-231 MCF-7 MRC-5
(TC1-S)2 4.4 ± 0.7 12.3 ± 0.8 30 ± 5
(TC3-S)2 17.0 ± 0.4 48.3 ± 1.2 27.3 ± 1.6
(TC5-S)2 17 ± 3 37 ± 1 > 300
(TC6-S)2 18.1 ± 0.9 19.5 ± 1.5 29.0 ± 0.6
(AH1-S)2 6.7 ± 0.5 4.6 ± 0.9 20.5 ± 1.0
(AH2-S)2 17.1 ± 1.5 45.3 ± 2.9 > 100
(SC2-S)2 45 ± 4 53 ± 1 91 ± 3
TE1 >200 >100 >100

aIC50 values were determined using standard MTT assays after 72-h incubations. Values are presented as mean ± SDM.