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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: Sci Immunol. 2018 Feb 23;3(20):eaam9841. doi: 10.1126/sciimmunol.aam9841

Fig. 2. Dectin-1 regulates innate IL-13.

Fig. 2

Clec7a+/+ and Clec7a−/− mice were sensitized and challenged with PBS or HDM. Seventy-two hours after the last challenge, lungs were harvested for determination of (A) levels of Il17A mRNA, (B) Il4 mRNA, (C) Il5 mRNA, (D) Il13 mRNA, (E) IL-13+CD4+ cells, and (F) FoxP3+CD4+ Tregs. (G) Numbers of IL-13+ ILCs in mice 24 hours after single PBS or HDM (100 µg) intratracheal inhalation. Rag1−/− or Rag1−/−Clec7a−/− mice were exposed to HDM as in Materials and Methods, and (H) AHR and (I) IL-13+ ILCs were determined. Data are means + SEM and are pooled from two independent experiments with n = 10 to 15 mice per group (A to E), representative of two experiments with n = 4 to 5 mice per group, or n = 6 to 13 animals per group (G to I). †P < 0.0001, as compared with PBS. *P < 0.05, **P < 0.01, as determined by one-way ANOVA followed by post hoc (Newman-Keuls) analysis.