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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: Sci Immunol. 2018 Feb 23;3(20):eaam9841. doi: 10.1126/sciimmunol.aam9841

Fig. 8. Invertebrate tropomyosin–dectin-1 interaction in mediating protection against allergic diseases.

Fig. 8

In healthy individuals, invertebrate tropomyosin binding of dectin-1 at mucosal surfaces results in suppression of IL-33–driven inflammation. In contrast, in allergic individuals, decreased levels of epithelial dectin-1 result in aberrant secretion of IL-33, which in turn drives IL-13 production from ILC2 and conditions local DCs to promote type 2 immune responses.